Please use this identifier to cite or link to this item:
https://ptsldigital.ukm.my/jspui/handle/123456789/393743| Title: | Platelet-activating factor (PAF) recepptor binding activity of the root bopf enicosanthellum pulchrum |
| Authors: | Noraziah Nordin Juriyati Jalil Ibrahim Jantan Shahnaz Murad |
| Conference Name: | New trends and challenges in Science and Technology : Proceedings of the Second UKM-UI Joint Seminar 2009 |
| Keywords: | Platelet-activating Enicosanthellum pulchrum |
| Conference Date: | 22/06/2009 |
| Conference Location: | Universiti Kebangsaan Malaysia |
| Abstract: | The hexane, ethyl acetate and methanol extracts of the root ofEnicosanthellum pulchrum (Annonaceae) were investigated for their inhibitory effects on platelet-activating factor (PAF) receptor binding to rabbit platelets using 3 H-PAF as a ligand. Cedro I, a known PAF antagonist from natural products was used as a positive control in the bioassay. Among the three extracts, the ethyl acetate was the most active with 85.6 % inhibition and gave IC50 value of 1.7 ?? 0.3 ug/ml. Further fractionation of this extract using vacuum liquid chromatography yielded six fractions (1- VI). Fraction V displayed the highest inhibitory activity of 71.2 %, followed by fraction VI with 67.9 % inhibition. Fraction I-IV exhibited moderate inhibitory effects between 40 to 60 % inhibition. The results suggest the possibility that the root extract may contain promising PAF receptor binding inhibitor. |
| Pages: | 5 |
| Call Number: | QC1.U463 2009 sem. |
| Publisher: | faculty of science and technology,Bangi, Selangor |
| Appears in Collections: | Seminar Papers/ Proceedings / Kertas Kerja Seminar/ Prosiding |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.