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https://ptsldigital.ukm.my/jspui/handle/123456789/393573| Title: | Inhibitory effects of flavonoids on the biosynthesis of prostaglandin E (PGE) in Human Plasma |
| Authors: | Dira Hefni Juriyati Jalil Khairana Husain Ibrahim Jantan |
| Conference Name: | New trends and challenges in Science and Technology : Proceedings of the Second UKM-UI Joint Seminar 2009 |
| Keywords: | Flavonoids Biosynthesis Human plasma |
| Conference Date: | 22/06/2009 |
| Conference Location: | Universiti Kebangsaan Malaysia |
| Abstract: | Nine flavonoids, apigenin (1), biochanin A (2), fisetin (3), jlavones (4), galangin (5), 3- hydroxyjlavone (6), myricetin (7), a-naphthojlavone (8) and J3-naphthojlavone (9), were investigated for their inhibitory effects on the biosynthesis of prostaglandin ??2 (PG??2) in human plasma in vitro. The anti-inflammatory effect was performed by measuring the PGE2 levels in plasma by using radioimmunoassay (RIA) technique. Among the nine jlavonoids, a-naphthojlavone (8) exhibited the highest inhibition of 63.3 %, followed by J3- naphthojlavone (9) and 3-hydroxyjlavone (6) with 60.2 % and 56.4 % inhibition respectively. Meanwhile, the lowest inhibitory effect was showed by jlavone (4) with only 11.4 % inhibition. The results indicate that a-naphthojlavone (8) and fJ-naphthojlavone (9) possess promising potent anti-inflammatory properties. Keywords: Anti-inflammatory; Prostaglandin ??2; Plasma; Flavonoids |
| Pages: | 6 |
| Call Number: | QC1.U463 2009 sem. |
| Publisher: | Faculty of Science and Technology,Bangi, Selangor |
| Appears in Collections: | Seminar Papers/ Proceedings / Kertas Kerja Seminar/ Prosiding |
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