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Title:	Vestibular and balance functions in ischemic stroke patients
Authors:	Sharifah Zainon Sayed Mohd Khan (P87535)
Supervisor:	Nor Haniza Abdul Wahat, Dr.
Keywords:	Vertigo Dizziness Stroke Universiti Kebangsaan Malaysia -- Dissertations Dissertations, Academic -- Malaysia
Issue Date:	10-Nov-2021
Description:	Vestibular and balance dysfunction can be one of the signs and symptoms of acute ischemic stroke. However, its characteristics as a stroke sequel are rarely reported. Vestibular and balance dysfunction could cause vertigo, dizziness, imbalance and fall. This cross-sectional study aims to identify vestibular and balance dysfunction in ischemic stroke patients during acute stage and three months post-stroke. Twenty-five patients with ischemic stroke aged between 42 to 78 years old (mean age= 59.04 ± 9.68 years) and 40 healthy control group (mean age= 58.65 ± 10.08 years) participated in this study. Subjects were tested using a battery of vestibular function testing (VFT), i.e. videonystagmography (VNG), cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs), video head impulse test (vHIT) and balance testing, i.e. Modified Clinical Test of Sensory Interactions in Balance (mCTSIB) and Timed Up and Go Test (TUG). In the control group, as the subjects' age increased, saccade latency was significantly longer (p= 0.020), the number of absent VEMPs responses increased, while total scores reduced significantly for both mCTSIB (p= 0.019) and TUG (p< 0.001). Among the acute stroke patients, 40% reported the presence of vestibular symptoms such as vertigo and imbalance. Abnormalities of smooth pursuit and saccade testing occurred in 84% of anterior circulation and posterior circulation stroke patients. When comparing control and stroke groups, there were no significant differences in the VOR gain values involving all the semicircular canals (p= 0.119) and absent cVEMPs responses (p= 0.402). However, it was found that in the stroke group, absent oVEMPs responses were significantly more frequent (p= 0.002), while the total mCTSIB score was significantly more reduced (p< 0.001). At three months post-stroke, significant improvements were observed in oVEMPs test abnormalities (p= 0.008) and TUG score (p= 0.031). In conclusion, the results indicated significant effects on the vestibular and balance test functions due to ischemic stroke. This study could be used as a benchmark in helping to improve the provision of health services in detecting and managing vestibular and balance functions in ischemic stroke patients.,Ijazah Doktor Falsafah
Pages:	220
Publisher:	UKM, Kuala Lumpur
Appears in Collections:	Faculty of Health Sciences / Fakulti Sains Kesihatan

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