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2. PHD Thesis / Tesis PHD
3. Faculty of Health Sciences / Fakulti Sains Kesihatan

Title:	The effectiveness of processing speed (remind) for cognitive remediation in improving outcomes of patients with first episode schizophrenia
Authors:	Naniyati Shuib (P83177)
Supervisor:	Mahadir Ahmad, Dr.
Keywords:	Schizophrenia Dissertations, Academic -- Malaysia Universiti Kebangsaan Malaysia -- Dissertations
Issue Date:	10-Feb-2020
Description:	Cognitive remediation (CR) has been implemented globally for decades to ameliorate cognitive impairment in schizophrenia. It is best to intervene early before the cognitive impairment in schizophrenia become worse overtime. Targeting lower-level cognitive function especially Processing Speed (PS) which is fundamentally the most deteriorated cognition in the first episode psychosis (FEP), might improve global cognition, psychopathology, and psychosocial functioning. This sequential explanatory mixed method study encompasses parallel single-blinded randomized controlled trial involved 92 participants randomly allocated to processing speed enhanced CR (ReMind) treatment arm (n=46), and standard CR (n=46) as an active comparator. Participants were selected from four hospitals in Klang Valley, Malaysia. They received 15 sessions of ReMind or CR for over 8 weeks. The neurocognitive, psychopathology, and psychosocial measures were assessed at baseline, post intervention and 3 months follow up. Cognitive function was measured by The Brief Assessment of Cognition Schizophrenia (BACS) Malay Version. The psychopathology was assessed by Positive and Negative Syndrome Scale (PANSS), and psychosocial functioning was measured by Social Functioning Scale (SFS), Schizophrenia Cognition Rating Scale (SCoRS), Social and Occupational Functioning Assessment Scale (SOFAS), and Schizophrenia Quality of Life Scale Revision 4 (SQLS-R4). A semi-structured interview was conducted at follow up to explore the participants' experience on the intervention. Multivariate analysis of variance (MANOVA), mixed model ANOVA and Regression Analysis were used to compare the treatment effect between groups measured at three points of time (t1, t2, t3), effect size, predicting processing speed, while thematic analysis was used for qualitative analysis. Study findings revealed that targeting processing speed is vital for improvement in higher-level performance in cognition, functional outcomes and symptom reduction, although the improvement is most significant in global cognition. Metacognitive strategies were possibly the active ingredients that accounted for impactful real-world recovery and maintained at three months follow up. Significance of the findings and the future direction are discussed.,Doktor Falsafah (PhD)
Pages:	474
Call Number:	WM203.N182e 2020 9 tesis
Publisher:	UKM, Kuala Lumpur
Appears in Collections:	Faculty of Health Sciences / Fakulti Sains Kesihatan

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