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Title: | Structure, Spectroscopy And Coordination Chemistry Of Oxo-Vanadium Hydrotris (3,5 Dimethyl Pyrazolyl) Borate With Benzoylthiourea Ligands |
Authors: | Aisha Ahmed Abobaker Mohammed (P49184) |
Supervisor: | Mohammad Bin Kassim, Professor Dr. |
Keywords: | Structure Chemistry Of Oxo-Vanadium Hydrotris Borate With Benzoylthiourea Ligands Spectroscopy Chemistry Of Oxo-Vanadium Hydrotris Borate With Benzoylthiourea Ligands Coordination Chemistry Of Oxo-Vanadium Hydrotris Borate With Benzoylthiourea Ligands Thiourea--Synthesis |
Issue Date: | 7-May-2013 |
Description: | Thirty-nine benzoylthiourea ligands (HL) with the general formula of [R3-Ph(CO)NH(CS)NR1R2], where R1 and R2 = alkyl and /or aryl groups and R3 = F, Cl, Br, OCH3, CH3, NO2 and phenyl functional groups were isolated and fully characterized by elemental analyses, melting point; IR, UV-Vis,1H and 13C NMR spectroscopies and X-ray crystallography. The benzoylthiourea ligands were successfully coordinated to oxovanadium(IV) ion to form the corresponding mixed-ligand complexes in the presence of a tridentate hydrotris(3,5-dimethylpyrazolyl)borate (Tp*) as co-ligand. All mixed ligand oxovanadium complexes were characterized on the basis of elemental analyses, melting point, IR, UV-Vis and EPR spectroscopies; mass spectrometry, cyclic voltammetry, magnetic susceptibility measurements and X-ray crystallography. Analytical and spectroscopic data of the ligands and their oxovanadium(IV) complexes indicated that the benzoylthiourea compounds coordinate as bidentate ligands. The X-ray crystallography structures of fifteen oxovanadium(IV) complexes were elucidated. In each structure, the vanadium centres adopted a pseudo-octahedral configuration formed by a bidentate (O,S) benzoylthiourea ligand, which occupy cis equatorial positions and the two nitrogen atoms from the tridentate (N,N��,N��)of the Tp* occupy the other cis equatorial positions, whereas the third nitrogen atom of Tp* is trans to the terminal oxo. The electronic spectra of the oxovanadium(IV) complexes exhibited multiple d-d transitions which suggested a distorted octahedral geometry for the six-coordinate V(IV) centre in a monomeric coordination environment. The room temperature cyclic voltammetry of the oxovanadium(IV) complexes revealed only one quasi-reversible oxidation wave for V(IV)/V(V) couples but spectroelectrochemical study for complex (Tp*VOL4] showed the molecules was fully reversible at -20C. Some complexes have been evaluated for their biological activities against selected pathogens and display moderate activity against the pathogenic bacteria and fungi.Tp*VOL2complex has been evaluated for the human hepatocellular carcinoma cancer cell line (HepG2) and Chang liver cells.The in vitro anticancer activities assay found that the complex were active against the HepG2 at high concentrations,.,PhD |
Pages: | 281 |
Call Number: | QD315 .M634 2013 |
Publisher: | UKM, Bangi |
Appears in Collections: | Faculty of Science and Technology / Fakulti Sains dan Teknologi |
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