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Title:	Burden of pneumococcal disease and acute otitis media and cost-effectiveness of introducing pneumococcal protein-d conjugate vaccine in the National Immunization Programme in Malaysia
Authors:	Namaitijiang Maimaiti (P51555)
Supervisor:	Syed Mohamed Aljunid, Professor Dato' Dr
Keywords:	Pneumococcal disease Acute otitis media Cost-effectiveness Protein-d conjugate vaccine National Immunization Programme Malaysia Otolaryngology
Issue Date:	27-Jun-2013
Description:	Background: The World Health Organization estimates that 1.6 million die every year from the disease, 0.7-1 million of which are children aged <5 years. However, Malaysia lacked credible national estimates of the burden of disease. In the absence of this data, policy-makers are unable to make decision on vaccine introduction Objective: To determine the clinical and cost burden of pneumococcal disease in Malaysia and the cost-effectiveness of introducing Pneumococcal Protein-D conjugate Vaccine in National Immunization Program in Malaysia for the prevention of invasive and non-invasive pneumococcal diseases Methodology: This is an economic evaluation study. A retrospective review of patient medical records from four public hospitals in Malaysia for the period of 2008-2009 was conducted to quantify the number of pediatric and adult hospital admissions attributable to pneumococcal Pneumonia, Septicemia, Meningitis and AOM. The costs of the pneumococcal disease were estimated using data from hospital cost system, the annual cost of the disease was estimated by pediatric and adult cases. The cost effectiveness analysis was run for PHiD-CV vaccine vs. no vaccination and PCV-13 vaccine, using Markov cohort model Result: Total 2,331,202 pneumococcal cases were estimated in Malaysian annually. Pneumococcal Pneumoniae estimated at 1,251,424 (54%) cases, 1,059,193 (45%) were AOM cases, 17,776 (0.8%) were Septicemia cases and 2,809 (0.2%) were Meningitis cases. The annual costs for Pneumococcal Pneumonia, Meningitis, Septicemia and AOM estimated at RM 1,402,609,013. The model predicted universal infant vaccination with PHiD-CV is expected to lead to a reduction in the incidence of all manifestations of pneumococcal disease, and importantly will save lives. The model also predicts that PHiD-CV is dominant over the PCV-13 Conclusion: the burden of pneumococcal pneumonia, septicemia, meningitis and AOM is high in Malaysia especially in children and the elderly. This can potentially be reduced by preventive measures such as vaccination.,Ph.D
Pages:	220
Call Number:	WV20.M217b 2013 9HUKM
Publisher:	UKM, Kuala Lumpur
Appears in Collections:	Faculty of Medicine / Fakulti Perubatan

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