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Title:	Performance analysis of surface plasmon resonance phase sensor based on laser feedback interferometry method
Authors:	Muhammad Kashif (P70163)
Supervisor:	Ahmad Ashrif Abu Bakar, Assoc. Prof. Ir. Dr.
Keywords:	Optical sensors Laser feedback interferometry Molecular interaction Surface plasmon resonance Universiti Kebangsaan Malaysia -- Dissertations
Issue Date:	17-Jul-2017
Description:	A significant research has been done in the area of optical sensors for the measurement of chemical and biological samples. A large number of methods have been used for the detection of molecular interaction. Surface plasmon resonance (SPR) is a unique optical sensing technique with a unique ability to monitor molecular binding in real-time for biological and chemical sensor applications. There are three different SPR approaches,intensity, angle and phase interrogation techniques. The SPR phase detection method is very sensitive to refractive index changes as compared to Angle and Intensity interrogation techniques. The SPR phase interferometer offers the advantages of spatial phase resolution and high sensitivity. The Kretschmann configuration was used to perform the SPR because it offers more efficient generation of surface plasmons in which thin metal film is directly attached to glass prism. The Glycerin was induced by peristaltic pump into the flow cell to flow above the film surface that rapidly changes the refractive index and refractive index directly influenced the phase of the output signal. This research proposed the laser feedback interferometry (LFI) method to enhance the performance of SPR sensor that provides the accurate measurements of small concentrations of an analyte. The main advantage of LFI compared to typical interferometer, such as, Mach-Zehnder interferometer is that, it has simpler experimental setup and more stable output signal. Furthermore, LFI can be employed in a small place and one optical axis makes it easy to control. Hence, the LFI technique was compared with Mach-Zehnder technique to look at its performance parameters. The performance of the proposed SPR LFI interferometer has better sensitivity, repeatability, and drift. The two interferometers are discussed in detail especially the LFI technique that provides high sensitivity of 1.33 ∗ 105 Deg/RIU that was 1.33 times higher than SPR MZI, which was 1 ∗ 105 Deg/RIU at 0.05% of Glycerin concentration. The LFI sensor's sensitivity was 16 times more than intensity interrogation method and 15 times better than angle interrogation method. Therefore, this work demonstrated the highly sensitive performance of the SPR LFI sensor as well as a discussion of the advantages and limitations. The comparative results showed that the performance of LFI technique and it will be better option for the detection of SPR at small concentration levels.,Certification of Master's/Doctoral Thesis" is not available
Pages:	128
Publisher:	UKM, Bangi
Appears in Collections:	Faculty of Science and Technology / Fakulti Sains dan Teknologi

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