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Title:	Photoplethymogram based cuff-less and continuous blood pressure measurement using pulse transit time
Authors:	Aws Zuhair Sameen Alsamray (P81554)
Supervisor:	Rosmina Jaafar, Dr.
Keywords:	Universiti Kebangsaan Malaysia -- Dissertations Dissertations, Academic -- Malaysia Blood pressure -- Measurement Pulse
Issue Date:	6-Dec-2019
Description:	Blood pressure (BP) is one of the vital health parameters that varies throughout the day. A single reading of high BP may not indicate hypertension, thus continuous monitoring of BP is normally recommended by the medical doctors to confirm diagnosis of hypertension being the most common cause of cardiovascular disease (CVD) and a global economic burden. In the last few decades, researchers investigated cuff-less and continuous BP measurement based on pulse transit time (PTT) as they discovered a linear relationship between the BP and PTT. The most common method for PTT estimation is calculating it from the time difference between synchronised R peak of electrocardiogram (ECG) signal and the maximum peak of photoplethysmogram (PPG) signal. To eliminate challenges involving acquisition of synchronised two different types of signals, this study proposes a new method for PTT calculation by acquiring PPG signals from carotid and toe simultaneously and modelling using autoregressive (ARX) system identification. The signals were acquired using a self-design data acquisition device customizing National Instrument NI-9239, AD8232 ECG module and Nellcor™ Flexible SpO₂ reusable PPG sensor. Factors such as subjects age, movement, and posture are tested for their influence on BP estimation among normotensive and hypertension subjects. The data of ECG and PPG as well as BP reading were recorded from 65 subjects age between 20 to 60 years. Results of the study have been validated in two stages. The first stage was validation of PTT values using system identification compared to the conventional PTT measurement method The results of PTT from both conventional and proposed system identification-based methods are highly correlated (R2 = 0.7808) and there is no significant difference between them (p < 0.05). The second stage was validation of the estimated BP using system identification by comparing it against the BP estimated using PTT from conventional method and the measured BP using the cuff-based method for all subjects. The results of estimated BP using the proposed system identification-based method to the measured BP obtained using the standard BP cuff measurement method are also highly correlated for both systolic blood pressure (SBP) (R2 = 0.8132) and diastolic blood pressure (DBP) (R2 = 0.8357). These results are within the acceptance range according to the Association of the Advancement of Medical Instrumentation (AAMI) standards. As a conclusion, results of the study have proven that PTT obtained from the carotid PPG and toe PPG using system identification approach yielded SBP and DBP estimations that are consistent with the values of the conventional BP cuff-method. The new proposed method has the advantage of being cuff-less and continuous BP measurement.,Ph.D.
Pages:	139
Call Number:	RC76.S236 2019 3 tesis
Publisher:	UKM, Bangi
Appears in Collections:	Faculty of Engineering and Built Environment / Fakulti Kejuruteraan dan Alam Bina

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