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https://ptsldigital.ukm.my/jspui/handle/123456789/485539| Title: | Profiles of biomarkers in gingival crevicular fluid and occurrence of boot resorption in traumatised and normal teeth during orthodontic treatment |
| Authors: | Ikmal Mohamad Jaafar (P62800) |
| Supervisor: | Rohaya Megat Abdul Wahab, Associate Professor Dr. |
| Keywords: | Orthodontic treatment Root resorption Lactate dehydrogenase (LDH) Human gingival crevicular fluid Teeth Dissertations, Academic -- Malaysia |
| Issue Date: | 28-May-2014 |
| Description: | Orthodontically induced inflammatory root resorption is an undesirable effect of orthodontic treatment. The aims of this prospective study were to investigate occurrence of root resorption and compare the activity levels of lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and concentration of nitric oxide (NO) in human gingival crevicular fluid (GCF) between traumatised and normal (non-traumatised) teeth during orthodontic alignment; and between teeth that developed root resorption and teeth with no root resorption after six months of orthodontic treatment. Twenty-one subjects (7 males and 14 females, aged 13 to 26 years) with 18 traumatised and 24 normal maxillary central incisors were recruited. GCF were sampled at pre-treatment (T0), 2 weeks after each orthodontic archwire change, in a sequence of 0.014-inch nickel titanium (NiTi) (T1), 0.018-inch NiTi (T2), 0.018 x 0.025-inch NiTi (T3) and 0.019 x 0.025-inch stainless steel (SS) (T4). LDH and AST enzyme activities were measured spectrophotometrically and NO level was quantified using Griess assay. Root resorption was measured from cone beam computed tomography (CBCT) images taken at pre-treatment (X0) and after 6 months of orthodontic treatment (X6). Following orthodontic alignment, 75% of normal incisors and 94.4% of traumatised incisors developed root resorption but the difference was not statistically significant (p > 0.05). Throughout the study period, LDH and AST activities were higher in the 'trauma' and 'root resorption' groups, but the differences were not statistically significant (p > 0.05). NO concentration in all groups was generally close to baseline (T0) although a statistically significant difference was observed between 'root resorption' and 'no root resorption' groups at T2 (p < 0.05). In conclusion, traumatised teeth without pre-existing root resorption had similar occurrence as normal teeth to develop root resorption during six months of orthodontic treatment. Current enzymological approach may not be sensitive enough to indicate the presence of root resorption in the early stage of orthodontic treatment,Ijazah Sarjana Doktor Pergigian (Klinikal Ortodontik) |
| Pages: | 103 |
| Call Number: | cd WU426.I261p 2014 9 |
| Publisher: | UKM, Kuala Lumpur |
| Appears in Collections: | Faculty of Dentistry / Fakulti Pergigian |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Profiles of biomarkers in gingival crevicular fluid and occurrence of boot resorption in traumatised and normal teeth during orthodontic treatment.PDF Restricted Access | Partial | 263.87 kB | Adobe PDF |  View/Open |
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