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Title:	Development and validation of a semi-quantitative food frequency questionnaire to characterise food intake related to cardiovascular disease
Authors:	Yeak Zu Wei (P67819)
Supervisor:	Tilakavati Karupiah, Prof. Madya Dr.
Keywords:	Cardiovascular Diseases Food Frequency Questionnaire Dietary fat Dissertations, Academic -- Malaysia Universiti Kebangsaan Malaysia -- Dissertations
Issue Date:	22-Jul-2016
Description:	Cardiovascular disease (CVD) has been shown to be the leading cause of mortality in Malaysian adults. Dietary fat, particularly saturates, are implicated in the aetiology of CVD risk. A rapid and reliable tool that can be appropriately applied to quantify dietary fat and fatty acid components of diets consumed by Malaysians is lacking. Therefore, the aim of this study is to develop and validate a food frequency questionnaire (FFQ) applicable to assess dietary fat intake in adult Malaysians. This study was divided into two phases; Phase 1 was the development of FFQ whilst Phase 2 provided for the validation of the FFQ. In Phase 1, 3 days diet records (3DDR) from 450 subjects in the Malaysian Lipid Study (MLS) was selected based on inclusion criteria, and were used to construct a food item list using the Block method. A food nutrient database was then built inclusive of macronutrients and individual fatty acids. A food album was also developed to facilitate the administration of the FFQ. In Phase 2, face validation (n=10) and content validation (n=8) were carried out. The final FFQ consisted of 240 food items. Relative validation was then carried out with 108 subjects (Malay=36, Chinese=35 and Indian=37; female=64, male=44; mean age=35.4±9.2yrs). Anthropometry, blood plasma triglycerides (TG) and dietary assessment for these subjects were assessed. The face validation of the FFQ indicated most food groups were well understood by lay persons and nutrition experts with the exception for fish, vegetables and organ meats groups (P<0.05). Mean time to complete the FFQ was 47.2±12.9 minutes. The mean difference for absolute intakes of total energy, carbohydrate, protein, total fat, saturated fatty acid (SFA), monounsaturated fatty acid (MUFA) and trans fatty acid (TFA) assessed by 3DDR and FFQ were not significant (all P>0.05) except for polyunsaturated fatty acid (PUFA). There was a significant correlation between FFQ and 3DDR assessments when comparing absolute intakes for total energy, carbohydrate, protein, total fat, SFA, MUFA, PUFA and TFA with correlations ranging from 0.23-0.44 (all P<0.05). PUFA, palmitic, stearic, linoleic and eicosapentaenoic acids were significantly correlated for comparisons between FFQ and plasma TG with correlations ranging between 0.20-0.37 (all P<0.05). Crossquartile classification indicated 62.9% to 78.7% of subjects were classified into thr same or adjacent quartiles and 1.9% to 11.1% subjects were grossly misclassified when comparing absolute intakes assessed by FFQ and 3DDR. Bland-Altman plots showed more than 90% of subjects were scattered within the limit of agreement for all nutrients between the FFQ and 3DDR. Between FFQ and plasma TG comparison, 57.3% to 75.1% subjects were classified into the same or adjacent quartiles while 4.6% to 20.4% subjects were grossly misclassified. This FFQ was developed appropriate to assessing macronutrient and fatty acid intakes in Malaysian adults. The FFQ is suitable to be applied in research studies to assess population diets contributing to cardiovascular disease risk.,Master of Health Science (Nutrition)
Pages:	205
Call Number:	WG120.Y38d 2016 9 tesis
Publisher:	UKM, Kuala Lumpur
Appears in Collections:	Faculty of Health Sciences / Fakulti Sains Kesihatan

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