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Title:	Cochleo-vestibular function in childhood cancer survivors receiving ototoxic chemotheraphy
Supervisor:	Nor Haniza Abdul Wahat, Dr.
Keywords:	Vestibulocochlear Nerve Universiti Kebangsaan Malaysia -- Dissertations Dissertations, Academic -- Malaysia
Issue Date:	22-Aug-2019
Description:	Childhood cancers are mostly treated with platinum-based chemotherapeutic drugs. However, the benefits of these drugs are reported to be limited due to its' ototoxicity effect. Many past studies reported on the drug's cochleotoxicity, but reports on the possibility of vestibulotoxicity of the drugs are lacking. This study aimed to objectively quantify the peripheral vestibular organs and balance function in childhood cancer survivors who received potentially ototoxic chemotherapy. Ocular and cervical Vestibular Evoked Myogenic Potentials (oVEMPs and cVEMPs), and video Head Impulse Test (vHIT) were employed to assess the function of otolith and semicircular canals (SCC). The balance function was assessed using the Bruininks Oseretsky Test of Motor Proficiency version II (BOT-2). The assessments were conducted with one recording only. Before that, subjects' hearing were measured using distortion product otoacoustic emission (DPOAE), and audiometry test. Thirteen post-chemotherapy subjects (mean age 14.37 ± 5.83 years old) treated with cisplatin or carboplatin in Hospital Canselor Tuanku Muhriz (HCTM), participated in the study. Findings from the vestibular and balance tests were then compared to that of 23 normal healthy subjects (mean age 11.93 ± 3.55 years old). Eleven subjects who received cisplatin showed high-frequency sensorineural hearing loss. oVEMPs, cVEMPs and vHIT results indicated no statistically significant difference (p>0.05) between post-chemotherapy and control groups. Nevertheless, small gain with the presence of saccades were observed in vHIT's results particularly in three subjects that may indicate poor SCC's function. On the other hand, BOT-2 results showed statistically significant difference (p<0.05) between the two groups. In conclusion, this study suggests that the peripheral vestibular organs in childhood cancer survivors receiving ototoxic chemotherapy drugs remained intact despite the presence of hearing loss, but the balance function was poor. From observation of three subjects with poor SCC's function, it is recommended that future studies should include more subjects and the peripheral vestibular organs should be measured before chemotherapy as these findings will enable a solid conclusion to be made on the possibility of the drug's vestibulotoxicity.,Master of Health Science (Hearing & Speech)
Pages:	183
Call Number:	9 Tesis WL330.N974c 2019
Publisher:	UKM, Kuala Lumpur
Appears in Collections:	Faculty of Health Sciences / Fakulti Sains Kesihatan

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