Please use this identifier to cite or link to this item:
https://ptsldigital.ukm.my/jspui/handle/123456789/457466| Title: | Clinical outcomes and survival rate of dental implants in diabetic patients according to glycaemic control : a systematic review and dose-response meta-analysis |
| Authors: | Tan Sze Jun (P91346) |
| Supervisor: | Badiah Baharin, Assoc. Prof. Dr. |
| Keywords: | Dental Implants Diabetes Mellitus Universiti Kebangsaan Malaysia -- Dissertations Dissertations, Academic -- Malaysia |
| Issue Date: | 1-Oct-2020 |
| Description: | Diabetes mellitus is considered a possible risk factor for peri-implant disease. Previous systematic reviews offer conflicting outcomes on survival rates and periimplant health in patients with or without diabetes. Diabetic assessment was mostly based on patient-reported information of glycaemic control, however, glycated haemoglobin (HbA1c) levels as an objective measure can better illustrate disease status. This systematic review aimed to compare the survival rate and clinical parameters of implants in patients with differing levels of glycaemic control based on their HbA1c values. Electronic search was completed on five databases, and manual examination of references was done up to March 2020. Research quality was evaluated using The Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool. Narrative synthesis and meta-analysis were performed, followed by further exploration with dose-response meta-analysis. Twenty-two articles were included for qualitative assessment, and nine of these for meta-analysis. Survival rate was high (92.6% to 100%) in the first 3 years for patient with HbA1c below 8%. Meta-analysis showed significantly more bleeding and deeper probing depth as glycaemic control worsened, when comparing HbA1c groups of less than 6%, 6.1-8% and 8.1-10%. However, results for these two outcomes were highly heterogeneous. Marginal bone loss was found to have a significant dose-response relationship with glycaemic index, supported by low heterogeneity statistics. Osseointegration was possibly protracted in patients with glycaemic levels beyond 8% but normalized by 6 months after implant placement. Inflammatory cytokines and bone biomarkers appeared to be adversely affected by poorer glycaemic control as well. Within the limits of this systematic review, the findings suggest possible dose-response trend of worsening clinical parameters in association with glycaemic control, particularly in marginal bone loss. Clinically, it is imperative to consider HbA1c values for risk assessment prior to placement and throughout the lifespan of the implant placed in a diabetic patient,Ijazah Sarjana Pergigian Klinikal (Periodontologi) |
| Pages: | 153 |
| Call Number: | WU640.T161c 2020 9 tesis |
| Publisher: | UKM, Kuala Lumpur |
| Appears in Collections: | Faculty of Dentistry / Fakulti Pergigian |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ukmvital_127455+Source01+Source010.PDF Restricted Access | 908.35 kB | Adobe PDF |  View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.