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https://ptsldigital.ukm.my/jspui/handle/123456789/456116| Title: | Development And Investigation Of Alginate/Gelatin Bilayer Hydrocolloid Films As Slow-Release Modern Wound Dressing |
| Authors: | Reshma Hj.Ayub Abdul Shakoor (Hnin Ei Thu) (P49294) |
| Supervisor: | Ng Shiow Fern, Dr. |
| Keywords: | Development Of Alginate/Gelatin Bilayer Hydrocolloid Films Investigation Of Alginate/Gelatin Bilayer Hydrocolloid Films Alginate/Gelatin Bilayer Hydrocolloid Films As Slow-Release Modern Wound Dressing Alginate (gelatin bilayer hydrocolloid film) |
| Issue Date: | 21-Feb-2013 |
| Description: | Sodium alginate (SA)/gelatin blend composite films have shown improved physical and mechanical properties compared to single component films. However, they have not been explored in drug delivery and wound healing applications. The aims of this research were to develop a novel SA/gelatin bilayer hydrocolloid film and investigate its potential as a slow-release modern wound dressing. The SA/gelatin bilayer film is composed of an upper layer impregnated with model drug (ibuprofen) and a drug-free lower layer, which acted as a rate-controlling membrane. Physical characterisation studies which include thickness, solvent loss, drug content uniformity, moisture vapour transmission rate, expansion percentage, rheology, tensile strength and film morphology were carried out. The chemical properties such as attenuated total reflection-fourier transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD) and storage stability were also studied. The bilayer films in vitro drug release and in vivo wound healing studies on animals were also investigated. Smooth and flexible bilayer films with desirable physical and mechanical properties were obtained. Film matrix with good integrity was observed and good compatibility between alginate and gelatin was shown by ATR-FTIR and XRD. The bilayers demonstrated low MVTR, slower hydration rate and lower drug flux in vitro compared to single layer inferring that bilayer may be useful for treating low suppurating wounds and suitable for slow release application on wound surfaces. A significant higher healing rate in vivo, with well-formed epidermis with faster granulation tissue formation was obtained with the bilayer films when compared to the controls. In conclusion, a novel SA/gelatin bilayer hydrocolloid film was developed and the results suggested that they can be exploited as slow-release wound dressings.,Master |
| Pages: | 199 |
| Call Number: | WO167 .H657d 2013 9 |
| Publisher: | UKM, Kuala Lumpur |
| Appears in Collections: | Faculty of Pharmacy / Fakulti Farmasi |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| ukmvital_74979+Source01+Source010.PDF Restricted Access | 7.38 MB | Adobe PDF |  View/Open |
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