Inhibition of prostaglandin andin E(PGE)production in human plasma by selected annonaceae species

Abstract

This study was carried out to explore the inhibitory effects of 64 methanolic en/de e from different parts of selected Annonaceae species, upon the production of prostai E2 in human plasma. Their anti-inflammatory properties were investigated by radioimmunoassay technique. Indomethacine (2 ppm) was used as a positive COI this study. Sixteen extracts from different parts of Annonaceae species showed inhibitory effects on the biosynthesis of prostaglandin E2. The highest inhibition extracts was displayed by Artabotrys surveolans (SM-804) with 96.1 %, while Triv. macrophyllus (AZ-42) gave the lowest inhibition, which is 38 %. For twig, Uvaria o (AZ-22) showed the highest inhibition of 95. 7 %, while 51 % inhibitory activity u prostaglandin E2 biosynthesis was observedfrom Pseuduvaria monticola (SM755). Polyalthia stenopetala (AZ-70) exhibited the highest activity with 89.7 % inhibitic Cyanthostemma argenteum (AZ-52a) showed the lowest inhibitory effect of67.2 %. J the root extracts, Pheanthus ophthalamicus (AZ-14) extract has the highesl inflammatory properties, which is 88.5 % while the lowest was showed by grandiflora (SM767), which only at 25 %. Our findings suggest that Annonnaceae J may contain useful compounds that can be developed into anti-inflammatory then agents. Keywords: Anti-inflammatory; Prostaglandin E2; Plasma; Annonaceae