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https://ptsldigital.ukm.my/jspui/handle/123456789/578379| Title: | The value of 18f-fluorodeoxyglucose –positron emission tomography/ computed tomography (18f- fdg pet/ct) in the staging and impact on the management of patients with nasopharyngeal carcinoma |
| Authors: | Sethu Thakachy Subha (UPM) Fathinul Fikri Ahmad Saad (UPM) Abdul Jalil Nordin (UPM) Saraiza Abu Bakar |
| Keywords: | 18F-FDG PET/CT Nasopharyngeal carcinoma AJCC-TNM staging) SUVmax Impact |
| Issue Date: | Jul-2017 |
| Description: | This study sought to prospectively evaluate the influence of contrasted fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDGPET/CT) in the staging of and impact on the management plan for treatment in patients with nasopharyngeal carcinoma (NPC). A total of 14 histologically proven NPC patients (mean age: 44.64±4.01years) were included in the study. These patients underwent contrasted Computed Tomography (CT) as well as 18F-FDGPET/CT imaging. Staging was based on the 7th edition of the American Joint Committee on Cancer Tumor Node Metastases (AJCCTNM)recommendations.The oncologist was asked to prospectively assign a treatment plan for all patients being evaluated by CT and 18F-FDGPET/CT. The treatment plans were compared with the incremental information supplied by the FDG-PET/CT. The maximum standardised uptake value (SUVmax) and the widest dimension of the primary tumour, cervical lymph nodes size and the distant metastatic lesions were quantified on the co-registered PET/CT images by two experienced nuclear radiologists. The contrasted 18F-FDGPET/CT changed the management intent in nine patients (64.7%). A univariate analysis showed that there were significant correlations between SUVmax and the size of the metastatic lymph nodes (R2 =0.0761, p<0.01), lymph node volume (R2=0.695, p<0.01) and the T-stage (R2=0.647, p<0.01). Multiple linear regression analysis revealed the tumour SUVmax to be the independent predictor of the T-stage (adjusted R2=0.889, p<0.05). The SUVmax may potentially be a surrogate marker for the T-stage in the NPC patients. The use of the combined imaging modality, 18F-FDGPET/CT, substantially impacted on the management strategy for treatment of NPC patients. |
| News Source: | Pertanika Journals |
| ISSN: | 0128-7680 |
| Volume: | 25 |
| Pages: | 687-696 |
| Publisher: | Universiti Putra Malaysia Press |
| Appears in Collections: | Journal Content Pages/ Kandungan Halaman Jurnal |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| ukmvital_115881+Source01+Source010.PDF | 278.68 kB | Adobe PDF |  View/Open |
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