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https://ptsldigital.ukm.my/jspui/handle/123456789/578379Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Sethu Thakachy Subha (UPM) | |
| dc.contributor.author | Fathinul Fikri Ahmad Saad (UPM) | |
| dc.contributor.author | Abdul Jalil Nordin (UPM) | |
| dc.contributor.author | Saraiza Abu Bakar | |
| dc.date.accessioned | 2023-11-06T03:01:00Z | - |
| dc.date.available | 2023-11-06T03:01:00Z | - |
| dc.date.issued | 2017-07 | |
| dc.identifier.issn | 0128-7680 | |
| dc.identifier.other | ukmvital:115881 | |
| dc.identifier.uri | https://ptsldigital.ukm.my/jspui/handle/123456789/578379 | - |
| dc.description | This study sought to prospectively evaluate the influence of contrasted fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDGPET/CT) in the staging of and impact on the management plan for treatment in patients with nasopharyngeal carcinoma (NPC). A total of 14 histologically proven NPC patients (mean age: 44.64±4.01years) were included in the study. These patients underwent contrasted Computed Tomography (CT) as well as 18F-FDGPET/CT imaging. Staging was based on the 7th edition of the American Joint Committee on Cancer Tumor Node Metastases (AJCCTNM)recommendations.The oncologist was asked to prospectively assign a treatment plan for all patients being evaluated by CT and 18F-FDGPET/CT. The treatment plans were compared with the incremental information supplied by the FDG-PET/CT. The maximum standardised uptake value (SUVmax) and the widest dimension of the primary tumour, cervical lymph nodes size and the distant metastatic lesions were quantified on the co-registered PET/CT images by two experienced nuclear radiologists. The contrasted 18F-FDGPET/CT changed the management intent in nine patients (64.7%). A univariate analysis showed that there were significant correlations between SUVmax and the size of the metastatic lymph nodes (R2 =0.0761, p<0.01), lymph node volume (R2=0.695, p<0.01) and the T-stage (R2=0.647, p<0.01). Multiple linear regression analysis revealed the tumour SUVmax to be the independent predictor of the T-stage (adjusted R2=0.889, p<0.05). The SUVmax may potentially be a surrogate marker for the T-stage in the NPC patients. The use of the combined imaging modality, 18F-FDGPET/CT, substantially impacted on the management strategy for treatment of NPC patients. | |
| dc.language.iso | en | |
| dc.publisher | Universiti Putra Malaysia Press | |
| dc.relation.haspart | Pertanika Journals | |
| dc.relation.uri | http://www.pertanika.upm.edu.my/regular_issues.php?jtype=2&journal=JST-25-3-7 | |
| dc.rights | UKM | |
| dc.subject | 18F-FDG PET/CT | |
| dc.subject | Nasopharyngeal carcinoma | |
| dc.subject | AJCC-TNM staging) | |
| dc.subject | SUVmax | |
| dc.subject | Impact | |
| dc.title | The value of 18f-fluorodeoxyglucose –positron emission tomography/ computed tomography (18f- fdg pet/ct) in the staging and impact on the management of patients with nasopharyngeal carcinoma | |
| dc.type | Journal Article | |
| dc.format.volume | 25 | |
| dc.format.pages | 687-696 | |
| dc.format.issue | 3 | |
| Appears in Collections: | Journal Content Pages/ Kandungan Halaman Jurnal | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ukmvital_115881+Source01+Source010.PDF | 278.68 kB | Adobe PDF |  View/Open |
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