Mutasi pada gen sistem kawal atur dua komponen vraS (TA pada kedudukan 700) dan graR (AG pada kedudukan 590) telah dikaitkan dengan kerintangan intermediat vankomisin dalam VISA Mu50. Namun demikian, peranan mutasi-mutasi ini dalam kerintangan tersebut masih belum dijelaskan. Kajian ini menggunakan pendekatan proteomik untuk menerangkan laluan pengawalaturan kerintangan intermediat vankomisin berkait vraSR/graSR. Jumlah protein diekstrak daripada 1 strain S. aureus klinikal rent...

Perkembangan teknologi gangguan RNA (RNAi) membolehkan kajian ke atas fungsi sasaran molekul tertentu dilakukan. Penggunaan RNAi bersama 5-fluorourasil (5-FU) mampu mengurangkan dos agen anti-kanser yang diperlukan. Integrasi di antara data mikroatur umum (Oncomine) dengan set data hasil kajian mikroatur terkini telah menghasilkan sebanyak 20 gen beregulasi menaik yang terlibat di dalam fungsi proliferasi dan kitaran sel. Kajian ini dijalankan untuk mengkaji peranan biologi gen gen...

On July 11, 1975 the Finance Minister of Singapore, Hon Sui Sen appointed two solicitors to investigate into the affairs of Haw Par Brothers International Ltd. The company was a Singapore - registered British managed and controlled multinational with substantial interests in Malaysia and Hong Kong. The move by the Singapore authorities arrived in the wake of a take-over tangle involving Malaysian interests. Haw par had announced that agreement had been reached with Pernas Securities Sdn. Bhd....

Discussion on the theme of "Development in the Eighties" requires to be adequately situated in terms of appropriate analytical foundations and through correct identification of the central issues. This paper seeks to provide a background that might aid in that discussion. First, I review some of the facts and figures describing the main contours of the contemporary world economy viewed in broad aggregative terms. One of the central problems that this raises is the question of the causes of th...