Please use this identifier to cite or link to this item: https://ptsldigital.ukm.my/jspui/handle/123456789/774865
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dc.contributor.advisorShahrul Sazliyana Shahrir, Dr.en_US
dc.contributor.advisorMohd Shahrir Mohamed Said, Assoc. Prof. Dr.en_US
dc.contributor.advisorMohd Redzuan Ismail, Dr.en_US
dc.contributor.advisorAsrul Abdul Wahab, Dr.en_US
dc.contributor.authorNarisa Sulaiman Sahari (P49420)en_US
dc.date.accessioned2024-07-16T01:29:00Z-
dc.date.available2024-07-16T01:29:00Z-
dc.date.issued2013-11-
dc.identifier.urihttps://ptsldigital.ukm.my/jspui/handle/123456789/774865-
dc.description.abstractBackground: Rheumatoid Arthritis (RA) patients are at increased risk of cardiovascular disease (CVD), with majority of CVD mortality in RA are attributed to accelerated atherosclerosis. Systemic inflammation in RA plays an important role in accelerated atherosclerosis. CIMT is an early surrogate marker for early atherosclerosis. Aim: To determine the prevalence of thickened CIMT among RA patient and to study the correlation of CIMT and disease activity in RA Method: This was a cross sectional study involving 40 RA patients (mean 44.78 ± 13.18 years) without CVD risk factors and 40 healthy sex matched controls (mean 44 ±12.30 years). Their demographic profile, disease characteristics and medications were evaluated. Disease activity was measured with DAS28 CRP score. Carotid ultrasound was performed to determine presence of thickened CIMT, which was defined as thickness of more than 75th percentile matched for age-and sex-matched normal controls. Statistical analysis was performed to determine the correlation between disease activity and other factors associated with thickened CIMT. Results: The thickened CIMT was significantly greater in RA patients with moderate to high disease activity (DAS28 CRP >3.2) than in RA patients who were in remission or had low disease activity (50% n=6) vs (17.8% n= 5); p value 0.037. Otherwise, no significant difference in the prevalence of thickened CIMT found in RA compared to control group (27.5% n= 11) vs. (12.5% n=5); p value 0.09. There was also no significant correlation between age, disease durations, IL 17, CRP and seropositivity (RF) found with thickened CIMT. Conclusion: Among RA patients, thickened CIMT were associated with RA patient with active disease (DAS28 >3.2). However, there’s no significant difference in prevalence of CIMT between RA patients and healthy control found in our study.en_US
dc.language.isoenen_US
dc.publisherUKM, Kuala Lumpuren_US
dc.relationFaculty of Medicine / Fakulti Perubatanen_US
dc.rightsUKMen_US
dc.subjectInternal medicineen_US
dc.subjectArthritis, Rheumatoiden_US
dc.subjectCardiovascular Diseasesen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectUniversiti Kebangsaan Malaysia -- Dissertationsen_US
dc.subjectDissertations, Academic -- Malaysiaen_US
dc.titleCarotid intima media thickness (Cimt) and its correlation with disease activity in rheumatoid arthritisen_US
dc.typeThesesen_US
dc.description.notes"Certification of Master's / Doctoral Thesis" is not availableen_US
dc.format.pages75en_US
dc.identifier.callno9HUKM WB 115.n229C 2013 tesisen_US
dc.identifier.barcode00002052590en_US
dc.format.degreeMaster of Medicineen_US
Appears in Collections:Faculty of Medicine / Fakulti Perubatan

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