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Please use this identifier to cite or link to this item: https://ptsldigital.ukm.my/jspui/handle/123456789/578666
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dc.contributor.authorKeong Bun Poh (UPSI)
dc.contributor.authorPhua Wan Jien (UPSI)
dc.date.accessioned2023-11-06T03:05:25Z-
dc.date.available2023-11-06T03:05:25Z-
dc.date.issued2017-11
dc.identifier.issn1511-3701
dc.identifier.otherukmvital:116112
dc.identifier.urihttps://ptsldigital.ukm.my/jspui/handle/123456789/578666-
dc.descriptionThe papaya plant yields a lot of by-products after its fruit is harvested. Papaya leaves contain a bio-active phytochemical that can serve as a potential source of natural antibacterial agents. Phytochemical screening has discovered that papaya leaf extract contains compounds such as alkaloids, tannins and saponins. Crude alkaloid detection by Dragendorff’s test was positive. Chemical structure characterisation of extracted crude alkaloids revealed by 1H-NMR spectrum testing was partial, as the spectrum identified only the chemical structure corresponding to aliphatic carbon compounds. Crude alkaloid dissolved in organic solvent dichloromethane showed no antifungal properties towards Candida albicans. Antibacterial properties of crude alkaloid dissolved in dichloromethane were selective on both Gram positive and negative bacteria. Kirby Bauer test results showed negative inhibition for both Staphylococcus aureus (Gram positive) and Salmonella typhi (Gram negative) but inhibition was positive for antibiotic resistant bacteria, MRSA (Gram positive) and Escherichia coli (Gram negative) bacteria. Inhibition efficacy increased with the amount of crude alkaloids used. The present study supports the use of papaya by-products as an alternative natural antibiotic for both the community and healthcare personnel.
dc.language.isoen
dc.publisherUniversiti Putra Malaysia Press
dc.relation.haspartPertanika Journals
dc.relation.urihttp://www.pertanika.upm.edu.my/regular_issues.php?jtype=1&journal=JTAS-40-4-11
dc.rightsUKM
dc.subjectAlkaloid
dc.subjectCarica papaya leaves
dc.subjectDichloromethane
dc.subject1H-NMR
dc.subjectAntibacterial and antifungal properties
dc.titleCharacterization of phytochemical compounds and antimicrobial activity of crude alkaloid from papaya (carica papaya l. var. eksotika) leaf extract
dc.typeJournal Article
dc.format.volume40
dc.format.pages667-676
dc.format.issue4
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