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Title:	Indoor environmental factors associated with asthma and asthma-related symptoms among adults :a comparison between summer and winter in Zunyi China
Authors:	Yu Jie (P51568)
Supervisor:	Noor Hassim Ismail, Prof. Dr.
Keywords:	Asthma Public health
Issue Date:	2-Dec-2014
Description:	There is increasing evidence for a possible association between asthma and asthma-related symptoms and indoor environmental quality in developing countries. This is the first study to examine potential effect modifiers of indoor environmental exposure on adult asthma and asthma-related symptoms in summer and winter seasons in China. To assess the association of indoor exposures and asthma and asthma-related symptoms, and its disparities in effects between winter and summer, we have completed two cross-sectional surveys of people aged ≥18 years in winter and summer seasons in the inner-city areas of Zunyi city, Guizhou Province, China. The subjects were selected using a multistage cluster sampling method. Data on asthma and asthma-related symptoms and selected home environmental factors were assessed by questionnaire. Pulmonary function measurements, including FVC, FEV1, FEV1/FVC and PEFR, were assessed and compared. Indoor and outdoor PM2.5 relative concentrations were monitored in selected houses. The studied Chinese adult respondents residing in Zunyi recorded lower prevalence rate of asthma in summer (0.8%) than in winter (1.8%). A significantly higher prevalence of asthma and asthma-related symptoms was found in winter (13.1%) than in summer (7.5%) (p<0.05). Among a variety of risk factors, age (OR = 1.032; 95% CI, 1.016-1.048), asthma and asthma-related symptoms in childhood (OR = 5.633; 95% CI, 3.701-8.573), familial history of asthma and asthma-related symptoms (OR = 2.741; 95% CI, 1.808-4.156), stove used for cooking or warming (OR = 1.992; 95% CI, 1.199-3.308), cooking oil fumes (OR = 2.077; 95% CI, 1.357-3.178), smoking status (OR = 2.790; 95% CI, 1.435-5.424), exposure to ETS (OR = 3.833; 95% CI, 2.432-6.040) and pets (OR = 2.272; 95% CI, 1.468-3.515) were associated with increased risks of asthma and asthma-related symptoms, especially in winter (p<0.05). PM2.5 levels in kitchen and bedroom was higher in winter than in summer (p<0.001). Negative relationship between lung function level and indoor kitchen and sleeping area PM2.5 relative concentrations was also revealed in winter rather than summer (p<0.05). The impact in lung function level among participants from indoor risk factor exposure was greater in winter than in summer (p<0.05). In conclusion, a positive association between kitchen, sleeping area risk factors and ETS exposure and the prevalence of adult asthma and asthma-related symptoms, especially in winter, was revealed in Zunyi. Given the extensive use of coal fuel and tobacco, public health efforts in the developing world, particularly in China that are concerned with respiratory health should address the risks of indoor air pollution exposure.,Certification of Master's/Doctoral Thesis" is not available
Pages:	366
Call Number:	tesis WA20.5.J61i 2014 9HUKM
Publisher:	UKM, Kuala Lumpur
Appears in Collections:	Faculty of Medicine / Fakulti Perubatan

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