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https://ptsldigital.ukm.my/jspui/handle/123456789/460369Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | Tilakavati Karupaiah, Prof. Madya Dr. | - |
| dc.contributor.author | Hjh Che Anishas Hj Che Idris (P45330) | - |
| dc.date.accessioned | 2023-09-14T08:02:00Z | - |
| dc.date.available | 2023-09-14T08:02:00Z | - |
| dc.date.issued | 2014-06-26 | - |
| dc.identifier.other | ukmvital:80490 | - |
| dc.identifier.uri | https://ptsldigital.ukm.my/jspui/handle/123456789/460369 | - |
| dc.description | Cardiovascular disease (CVD) is a major cause of mortality in developing countries. Antioxidants are reported to inhibit the progression of atherosclerosis development and reduce the incidence of CVD. The oil palm fruit has been identified as an excellent source of two major phytochemicals, namely vitamin E (tocopherols and tocotrienols) and carotenoids. Recently, the palm fruit has also been identified as a rich source of phenolic compounds. This study aimed to evaluate the antioxidant effect of these phenolic compounds singly or in combination against atherosclerosis development in an animal model. Thirty-two New Zealand White rabbits were divided into four groups of 8 and fed an atherogenic diet for 100 days. The diets uniformly provided 35% energy from fat and 0.15% cholesterol (w/w). The fat comprised 72.3% saturated fatty acids, primarily as C12:0+C14:0. Group 1; the Control group (CTR) was fed the atherogenic diet, and Group 2; the Vitamin E group (VIT E) was fed the atherogenic diet with added vitamin E (500mg vitamin E/kg diet). Animals in Groups 1 and 2 were provided distilled water as their drinking fluid. Group 3; the palm phenolics group (OPP) was fed the atherogenic diet and palm phenolics (at a concentration of 1500 mg gallic acid equivalent/L (mg GAE/L)) provided as drinking fluid, while Group 4 received a combination of vitamin E and oil palm phenolics (VIT E+OPP). The vitamin E for the group 4 animals, was added in the atherogenic diet while OPP (1500mg GAE/L) was provided in their drinking fluid. Animals were fed diets ad libitum and had free access to drinking fluids. Mean body weights of the rabbits, prior to and at the end of the study, were not significantly different among all dietary groups after 100 days feeding (p>0.05). Results from the analysis of lipid profiles and antioxidant assays were not significantly different among groups (p>0.05). However, fibrous plaques were associated with the CTR group (8.90±5.41%) and on a comparatively smaller but significant degree (p<0.05) in the VIT E (2.88±2.01%) and OPP (1.48±4.45%) groups. Fibrous plaques were not detected in the VIT E+OPP group. Similar trends for fatty plaque development were observed in these groups. Findings in this study suggest that despite the high-fat atherogenic diet, oil palm vitamin E and oil palm phenolics individually inhibited atherosclerotic lesion development. However, a major finding was oil palm vitamin E in combination with oil palm phenolics mediated the greatest protective effect against the development of atherosclerotic lesions in this animal model.,Penyakit jantung merupakan penyebab utama kematian di negara-negara yang sedang membangun. Antioksidan telah dilaporkan dapat merencat pembentukan plak aterosklerotik dan seterusnya mengurangkan kejadian penyakit jantung. Buah sawit telah dikenalpasti sebagai sumber utama kepada dua kumpulan fitonutrien terbaik iaitu vitamin E (tokoferol dan tokotrienol) dan karotenoid. Baru-baru ini, buah sawit juga didapati mengandungi sumber yang kaya dengan kompaun fenolik daripada hasil buangan sisa sawit melalui kaedah yang telah dibangunkan dan dipatenkan. Kajian ini bertujuan untuk mengkaji kesan antioksidan daripada kedua-dua fitonutrien buah sawit dari segi penggunaan secara sendirian atau gabungan ke atas pembentukan plak aterosklerotik melalui model haiwan. Tiga-puluh dua ekor arnab jantan baka New Zealand White dibahagikan kepada empat kumpulan, 8 ekor dalam setiap kumpulan diberi diet aterogenik selama 100 hari. Diet ini membekalkan 35% tenaga daripada lemak dan 0.15% kolesterol (w/w). Lemak dalam diet aterogenik tersebut terdiri daripada 72.3% asid lemak tepu dengan sebahagian besar terdiri daripada C12:0+C14:0. Kumpulan 1; adalah kumpulan kawalan (CTR) diberi diet aterogenik sahaja. Kumpulan 2; iaitu kumpulan Vitamin E (VIT E) diberi diet aterogenik yang dicampurkan dengan vitamin E (500mg vitamin E/kg diet). Kedua-dua kumpulan ini diberi air suling sebagai air minuman. Kumpulan 3; iaitu kumpulan Fenolik Sawit (OPP) diberi diet aterogenik dan larutan fenolik sawit (pada kepekatan 1500 mg asid gallik setara/L (mg GAE/L)) diberi sebagai air minumannya, manakala Kumpulan 4 menerima diet aterogenik dengan penambahan vitamin E (500mg vitamin E/kg diet) dan larutan fenolik sawit (1500mg GAE/L) sebagai air minumannya. Kesemua haiwan kajian diberi makanan secara ad libitum dan dibekalkan dengan air minuman tanpa had. Purata berat badan arnab daripada semua kumpulan arnab tidak menunjukkan perbezaan yang ketara sebelum dan selepas pemberian diet ujian selama 100 hari (p>0.05). Profil lipid dan esei antioksidan antara kesemua kumpulan haiwan kajian juga didapati tiada perbezaan yang signifikan (p>0.05). Namun, perbezaan yang ketara terdapat pada pembentukan plak fibrous pada Kumpulan CTR (8.90�5.41%) dan pada tahap perbezaan yang kecil namum masih ketara (p<0.05) pada Kumpulan VIT E (2.88�2.01%) dan Kumpulan OPP (1.48�4.45%). Manakala didapati tiada pembentukan plak fibrous pada haiwan Kumpulan VIT E+OPP. Begitu juga didapati pembentukan plak lemak menunjukkan corak yang sama. Secara keseluruhannya, walaupun kesemua haiwan kajian telah diberi diet yang aterogenik, didapati penggunaan vitamin E dan fenolik sawit masing-masing dapat merencatkan pembentukan plak aterosklerotik. Tetapi apabila pengunaan kedua-dua antioksidan tersebut digabungkan,didapati kesan tahap perencatan adalah lebih tinggi terhadap pembentukan plak aterosklerosis di dalam model haiwan ini.,Bachelor | - |
| dc.language.iso | eng | - |
| dc.publisher | UKM, Kuala Lumpur | - |
| dc.relation | Faculty of Health Sciences / Fakulti Sains Kesihatan | - |
| dc.rights | UKM | - |
| dc.subject | Palm antioxidants | - |
| dc.subject | Atherosclerosis | - |
| dc.subject | Antioxidants | - |
| dc.title | A comparative study of palm antioxidants: palm phenolics, palm vitamin e and their combination in an experimental atherosclerosis rabbit model | - |
| dc.type | theses | - |
| dc.format.pages | 166 | - |
| dc.identifier.callno | QU179.C514c 2014 9 tesis | - |
| Appears in Collections: | Faculty of Health Sciences / Fakulti Sains Kesihatan | |
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|---|---|---|---|---|
| ukmvital_80490+SOURCE1+SOURCE1.0.PDF Restricted Access | 3.81 MB | Adobe PDF |  View/Open |
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