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Please use this identifier to cite or link to this item: https://ptsldigital.ukm.my/jspui/handle/123456789/578361
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dc.contributor.authorNesti Fronika Sianipar
dc.contributor.authorRagapadmi Purnamaningsih
dc.date.accessioned2023-11-06T03:00:47Z-
dc.date.available2023-11-06T03:00:47Z-
dc.date.issued2018-02
dc.identifier.issn1511-3701
dc.identifier.otherukmvital:115866
dc.identifier.urihttps://ptsldigital.ukm.my/jspui/handle/123456789/578361-
dc.descriptionRodent tuber (Typhonium flagelliforme Lodd.), which is a well known herbal plant from the Araceae family, is know for its anticancer activities. The genetic variation of rodent tuber is low due to its commonly applied vegetative propagation methods. Thus, its genetic variation has to be increased to obtain a new and superior plant containing a high amount of anticancer compounds. The aim of this study was to analyse the chemical compounds of the leaves and tubers of rodent tuber’ mutant and non irradiated (control) plants by GCMS method. In this study, in vitro calli of rodent tuber was irradiated with 6 Gy of gamma ray which produced mutant plantlets which was genetially different from non irradiated (control) plants. Mutant plantlets had been acclimated and propagated in the greenhouse to obtain the 6th generation vegetative mutant clones (MV6), which are stable superior mutants. The results indicated that MV6 contained six new anticancer compounds in the leaves and four new anticancer compounds in the tubers which have not been detected in control. The new anticancer compounds present in leaves and tubers were identified by GC-MS. They are hexadecanoic acid methyl ester, octadecadienoic acid, phytol¸ gammasitosterol, eicosane, geranylgeraniol, squalene, octacosane and 7-pentadecyne. MV6, is the new superior variety and a potential source of anticancer drugs.
dc.language.isoen
dc.publisherUniversiti Putra Malaysia Press
dc.relation.haspartPertanika Journals
dc.relation.urihttp://www.pertanika.upm.edu.my/regular_issues.php?jtype=1&journal=JTAS-41-1-2
dc.rightsUKM
dc.subjectTyphonium flagelliforme Lodd
dc.subjectNew superior mutant
dc.subjectAnticancer bioactive component
dc.subjectIndonesia
dc.titleEnhancement of the contents of anticancer bioactive compounds in mutant clones of rodent tuber (typhonium flagelliforme lodd.) based on gc-ms analysis
dc.typeJournal Article
dc.format.volume41
dc.format.pages305-320
dc.format.issue1
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