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Please use this identifier to cite or link to this item: https://ptsldigital.ukm.my/jspui/handle/123456789/578236
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dc.contributor.authorOghenebrorhie Mavis Oghenochuko
dc.contributor.authorJohnny Olufemi Olukunle
dc.contributor.authorOlubukola Tolulope Adenubi
dc.contributor.authorOlusola Lawrence Ajayi
dc.contributor.authorFakilahyel Musa Mshelbwala
dc.contributor.authorIkililu Abdulraheem
dc.contributor.authorJames Taiwo Apantaku
dc.contributor.authorOlabosede Vivian Anuoluwapo Takeet
dc.contributor.authorTunde Isaac Omoniyi
dc.contributor.authorGodfrey Nnamdi Ezeri
dc.date.accessioned2023-11-06T02:59:26Z-
dc.date.available2023-11-06T02:59:26Z-
dc.date.issued2019-08
dc.identifier.issn1511-3701
dc.identifier.otherukmvital:115761
dc.identifier.urihttps://ptsldigital.ukm.my/jspui/handle/123456789/578236-
dc.descriptionAdverse effects of Allium cepa bulb has been well overlooked because it is natural and assumed safe. This study investigated the lethal doses and histopathological changes in liver and kidney of healthy Clarias gariepinus sub-adult exposed to red Allium cepa bulb at varying concentrations (200, 150, 100, 50 and 25 g/kg) of A. cepa via diet and bath (5, 3, 1.5, 0.7 and 0.4 g/L) for two weeks. Specimens were sacrificed, liver and kidneys collected, processed and examined for histopathological changes. Proximate analysis, qualitative and quantitative phytochemistry was determined using standard methods. Brine Shrimp lethality assay (BSLA), LD50 and LC50 of the onion on experimental fish were investigated. Saponins, tannins, phenols, flavonoids and alkaloids were present. LC50 of the onion extract was between 0. 51 mg and 0.64 mg in the BSLA while mean LD50 and LC50 for dietary and bath treatments were 447.1 g/kg and 12.2 g/L. Liver histopathology showed vacuolar degeneration of the hepatocytes and congestion of central vein, while necrosis of the epithelial cells and haemosiderosis were observed in the kidney at high concentrations. Allium cepa is safe in fish when administered in lower dose either through diet or bath exposure but was toxic at high dose.
dc.language.isoen
dc.publisherUniversiti Putra Malaysia Press
dc.relation.haspartPertanika Journals
dc.relation.urihttp://www.pertanika.upm.edu.my/regular_issues.php?jtype=1
dc.rightsUKM
dc.subjectAllium cepa
dc.subjectClarias gariepinus
dc.subjectHistopathology
dc.subjectPhytochemistry
dc.subjectToxicity
dc.titleLethal Doses and Histopathological Changes in Liver and Kidney of Healthy Clarias gariepinus Sub-adult Exposed to Red Allium cepa Linn. Bulb
dc.typeJournal Article
dc.format.volume42
dc.format.pages1081-1096
dc.format.issue3
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