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https://ptsldigital.ukm.my/jspui/handle/123456789/578080| Title: | Ethnic differences in the prevalence, clinical outcome and cag pathogenicity island (cagPAi) virulence gene profiles of helicobacter pylori strains from Malaysia |
| Authors: | Alfizah H (Universiti Kebangsaan Malaysia) Rizal A. M (Universiti Kebangsaan Malaysia) Ramelah M (Universiti Kebangsaan Malaysia) |
| Keywords: | Helicobacter pylori Cag pathogenicity island Virulence genes Peptic ulcer diseases Nonpeptic ulcer dyspepsia Ethnicity Malaysia |
| Issue Date: | Nov-2013 |
| Description: | Different Helicobacter pylori genes may be well conserved within different ethnic groups and could give rise to different clinical outcomes. In this study, we demonstrated a low prevalence of H. pylori infection (19.2%) which is in concordance with the current trend demostrated locally and abroad. The Indians had the highest prevalence of H. pylori infection among other ethnic groups (Malays= 8.6 %, Chinese= 24.3 %, Indians= 33.9%). cagM and cagT were the most predominant genes found (63.4% for each), followed by cagA (62.2 %), cagE (48.2%), cag6-7 (46.3%), cag10 (42.1%), cag13 (4.9%) and IS605 (3.7%). No significant association was found between H. pylori infection and H. pylori genes with ethnic groups or clinical outcomes. Indians who had a combination of cagA/E/M genes of H. pylori were likely to be associated with 21-time of having non-ulcer dyspepsia (NUD) than peptic ulcer disease (PUD). Therefore, these genes may serve as useful markers in predicting the clinical presentation of a H. pylori infection among Indians in our studied population. Hence, this preliminary data might explain why Indians have a low prevalence of gastric cancer and peptic ulcer disease despite having persistently high prevalence of H.pylori infection for many decades (“Indian enigma”) in Malaysian patients. |
| News Source: | Pertanika Journal of Tropical Agricultural Science |
| ISSN: | 1511-3701 |
| Volume: | 36 |
| Pages: | 289-298 |
| Publisher: | Universiti Putra Malaysia Press |
| Appears in Collections: | Journal Content Pages/ Kandungan Halaman Jurnal |
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|---|---|---|---|---|
| ukmvital_131101+Source01+Source010.PDF | 349.02 kB | Adobe PDF |  View/Open |
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