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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | Azmin Sham Rambely, Assoc. Prof. Dr. | - |
| dc.contributor.author | Alqarni Awatif Jahman (P95702) | - |
| dc.date.accessioned | 2023-10-13T09:47:01Z | - |
| dc.date.available | 2023-10-13T09:47:01Z | - |
| dc.date.issued | 2021-07-15 | - |
| dc.identifier.other | ukmvital:130609 | - |
| dc.identifier.uri | https://ptsldigital.ukm.my/jspui/handle/123456789/500638 | - |
| dc.description | Stroke is one of the main causes of disability and mortality in the world. Stroke is caused by the loss of brain functions due to the problem in the cerebral blood flow, which leads to the death of brain cells. The properties and characterization of stem cells have been established as multistage cell lineages in various biological and mathematical studies. This motivates for research to dynamically demonstrate functions of the stem cells that help tissue of the brain by two types of stem cells sources, namely when a stroke occurs and during the recovery stage. In addition, this study aimed to determine the effect of the microglia activation on the brain during a stroke and influence of the damage caused by microglia on the healthy brain cells through developing a mathematical model of strokemicroglia damage (SMD); to study the interactions between microglia and endogenous neural stem cells during the recovery stage after the stroke via developing a mathematical model of stroke-microglia-neural stem cells-recovery (SMNR); to determine functions of transplanted stem cells on the dynamics of immune cells by developing a mathematical model of transplanted stem cells-damaged brain cells-microglia-stroke (TDMS); to illustrate the effect of transplant stem cells and progenitor cells into brain after a stroke on the dynamics of the stem cells and progenitor cells replacement for the damaged brain cells through developing mathematical models of stem cells-progenitor cells-neural differentiated cells-brain cells (SPNB) and progenitor cells-mature cellsbrain cells (PNB). Five dynamic models have been proposed for the case of the existence of an ischemic stroke in order to understand various-species interactions so as to help the brain uses stem cell treatment and to test the stability of these models. The behaviour of dynamics models is also discussed by using endogenous neural stem cells and exogenous stem cell transplantation in different stages of a stroke. Mathematical models have been developed to investigate dynamically, analytically, and numerically the effect of stem cells dynamic in a stroke model through different time and stages with various functions of stem cells. The models are simulated using the fourth-order Runge- Kutta method. We look at the analysis and simulation models, where it can be deduced that the stem cells are able to inhibit inflammation and replace damaged cells through these functions: stem cell transplantation can decrease infarct volume, improve the neurological role, decreasing the inflammation and immunomodulatory, cell replacement, neuroprotection, and boost endogenous neurogenesis. From analyzing the SMD and SMNR, it was found that microglia have useful and harmful roles after ischemic stroke and functions on stimulating endogenous neural stem cells to support the neurogenesis. The TDMS model illustrates the effect of stem cell transplantation on immunomodulatory in early-phase from the onset of a stroke. The SPNB model demonstrates the cell replacement function of stem cell transplantation by the proliferation and differentiation process in the brain. The PNB model describes the migration of the mature brain cells in the brain to various types of nerve cells. The dynamical behaviours are investigated, with the local stability near all the positive equilibrium points is obtained. The numerical simulation using Mathematica with NDSolve command is used to solve and study the dynamical behaviour of the proposed models. Analysis and simulation of developed models indicate that the important role of stem cells transplanted on modified immune responses in early phase from a stroke through determining the effect of transplanted stem cells on the immune cells by inhibition of the inflammation, decrease in secondary injury processes and stimulation of brain repair after stroke.,Ph.D | - |
| dc.language.iso | eng | - |
| dc.publisher | UKM, Bangi | - |
| dc.relation | Faculty of Science and Technology / Fakulti Sains dan Teknologi | - |
| dc.rights | UKM | - |
| dc.subject | Stem cells | - |
| dc.subject | Embryonic stem cells | - |
| dc.subject | Universiti Kebangsaan Malaysia -- Dissertations | - |
| dc.subject | Dissertations, Academic -- Malaysia | - |
| dc.title | Mathematical modelling and dynamic simulations of treatment of a stroke disease by stem cells | - |
| dc.type | Theses | - |
| dc.format.pages | 149 | - |
| dc.identifier.callno | QH588.S83A437 2021 tesis | - |
| dc.identifier.barcode | 006839(2022) | - |
| Appears in Collections: | Faculty of Science and Technology / Fakulti Sains dan Teknologi | |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| ukmvital_130609+SOURCE1+SOURCE1.0.PDF Restricted Access | 1.41 MB | Adobe PDF |  View/Open |
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