The study of surface modified magnetite nanoclusters : synthesis, characterization and potential biomedical applications

Haw Choon Yian (P52634)

Please use this identifier to cite or link to this item: https://ptsldigital.ukm.my/jspui/handle/123456789/499446

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DC Field	Value	Language
dc.contributor.advisor	Chia Chin Hua, Dr.
dc.contributor.author	Haw Choon Yian (P52634)
dc.date.accessioned	2023-10-13T09:32:03Z	-
dc.date.available	2023-10-13T09:32:03Z	-
dc.date.issued	2013-08-15
dc.identifier.other	ukmvital:74688
dc.identifier.uri	https://ptsldigital.ukm.my/jspui/handle/123456789/499446	-
dc.description	In this study, magnetite (Fe3O4) nanoparticles have been synthesized using different approaches through chemical methods and physical treatments. The nanometer-sized Fe3O4 nanoparticles were prepared by co-precipitation, hydrothermal treatment and thermal decomposition methods. Different surface modifiers were applied to the Fe3O4 nanoparticles to induce the formation of nano-sized clusters. The modifier materials that have been employed in the present study are biodegradable, biocompatible and non-hazardous to the environment. This study involved using the amorphous silica to retain randomized dispersion of Fe3O4 nanoparticles in a cluster. The experimental results showed that the morphology of silica coated Fe3O4 nanoclusters was strongly governed by the reaction parameters including concentration of tetraethyl orthosilicate (TEOS) monomer, choice of alcohol with different polarity, proportional concentration of alcohol-water and concentration of alkaline catalyst. It was found that the Fe3O4 nanoclusters were randomly dispersed within a silica particle. The clusters were shown to be superparamagnetic which was confirmed by vibrating samples magnetometer (VSM). The effect of clustering Fe3O4 nanoparticles on proton transverse R2 relaxation rate was investigated. Fe3O4 nanoclusters were characterized with high resolution transmission electron microscopy (HR-TEM), dynamic light scattering (DLS) and superconducting quantum interference device (SQUID) magnetometry. The surface modified Fe3O4 nanoclusters with polysorbate surfactant, Tween-20 and silica were prepared in both water-based and agar based form, respectively. The samples were measured in a NMR relaxometer to determine the transverse relaxation rate (R2). The results showed that when surface modified Fe3O4 nanoclusters were measured in water suspension, both Tween-20 and silica coated samples showed time-dependent behaviour. This behaviour was attributed to a morphological change of the clusters in solution. Agar-based samples, where the morphology of the clusters is fixed showed non time-dependent behaviour for both surface modified Fe3O4 nanoclusters. Biodegradable chitosan (CTS) has also been used in preparing the Fe3O4 nanoclusters in order to study the contrast enhancement in magnetic resonance imaging (MRI) using custom made Perspex phantoms. A hydrothermal method was adopted in order to obtain the high crystallinity of the particles. The T2-weighted MR image of the particles contained using Perspex phantom suggested that the as-prepared Fe3O4 nanoclusters were a viable candidate for MRI T2-weighted contrast agent.,Ph.D
dc.language.iso	eng
dc.publisher	UKM, Bangi
dc.relation	Faculty of Science and Technology / Fakulti Sains dan Teknologi
dc.rights	UKM
dc.subject	Magnetite nanoclusters
dc.subject	Biomedical
dc.subject	Nanostructures
dc.title	The study of surface modified magnetite nanoclusters : synthesis, characterization and potential biomedical applications
dc.type	Theses
dc.format.pages	191
dc.identifier.callno	QC176.8.N35.H374 2013
dc.identifier.barcode	000732
Appears in Collections:	Faculty of Science and Technology / Fakulti Sains dan Teknologi

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