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https://ptsldigital.ukm.my/jspui/handle/123456789/499397| Title: | Synthesis, characterization, conductometric and biological studies of some new ammonium organic derivatives of carboxylate salts |
| Authors: | Leila Narimani (P51605) |
| Supervisor: | Bohari M. Yamin, Prof. Dr. |
| Keywords: | Ammonium Carboxylate salts Organic Universiti Kebangsaan Malaysia -- Dissertations Dissertations, Academic -- Malaysia |
| Issue Date: | 16-Dec-2013 |
| Description: | A total of twenty one ammonium organic salts of ethylenediammonium thiocyanate hemioxalate (Ι), ethylenediammonium thiocyanate hemiadipate (ΙΙ), ethylenediammonium fumarate (Ш), ethylenediammonium bis(hydrogen succinate) (ΙV), ethylenediammonium thiocyanate hemiazelate (V), ethylenediammonium thiocyanate hemisebacate (VΙ), ethylenediammonium 3,5-dinitro benzoate (VΙΙ), ethylenediammonium bis (thiocyanate) (VΙΙΙ), 1,2-propanediammonium oxalate (ΙX), 1,3-propanediammonium oxalate (X), bis (2,6-diamino pyridinium) oxalate (XI), 2,6-diamino pyridinium hydrogen malonate (XII), bis(2,6-diaminopyridinium) adipate adipic acid mono hydrate (XIII), bis(2,6-diaminopyridinium) maleate (XIV), bis(2,6-diaminopyridinium) fumarate (XV), 2, 4-diamino-6-methyl-1, 3, 5-triazin-1-ium hydrogen oxalate (XVI), 2, 4-diamino-6-methyl-1, 3, 5-triazin-1-ium thiocyanate (XVII), anilinium hemioxalate (XVIII), bis(anilinium) succinate (XIX), 2-amino anilinium succinate succinic acid (XX) and 2-amino anilinium glutarate glutaric acid (XXI) were synthesized and characterized by microelemental analysis, infrared (IR), nuclear magnetic resonance (NMR) and ultra violet-visible (UV) spectroscopic techniques. The structure of thirteen compounds were investigated by single X-ray diffractometry. In all the structures the intermolecular hydrogen bonds play an important role for stability in the solid state by the formation of one, two or three dimensional networks. TGA studies on different compounds showed different steps of decomposition. Compounds (XI)-(XV) displayed antibacterial activity against Gram-positive bacteria (Streptococcus pyogenes, Staphylococcus aureus, Enterococcus faecalis), Gram-negative bacteria (Salmonella typhi, Vibrio parahaemolyticus, Escherichia coli, Proteus mirabilis, Enterobacter aerogenes, Pseudomonas aeruginosa) and methicillin-resistant Staphylococcus aureus (MRSA). Other salts show no activity against the bacteria. All the compounds show low toxicity against Vero cells. The molar conductivity (Λm) of salts are between 209 and 453 ohm-1cm2mol-1 with maximum value of 453 ohm-1cm2mol-1 for compound (Ι). The thermodynamic parameters of the complexation of a tetraaza ammonium salt namely 5,5,7,12,14,14-hexamethyl-1,8-diaza-4,11-diazoniacyclotetradeca-4,11-dienedichloride tri-hydrate with different target ions (Co2+, Cu2+, Zn2+ and Ni2+) in pure water, pure methanol and binary solvents (water-methanol) were determined using the non-linear least-squares GENPLOT computer program and by varying the molar conductance as a function of mole ratios.,Ph.D. |
| Pages: | 241 |
| Call Number: | QD305.A8N347 2013 tesis |
| Publisher: | UKM, Bangi |
| Appears in Collections: | Faculty of Science and Technology / Fakulti Sains dan Teknologi |
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|---|---|---|---|---|
| ukmvital_71569+Source01+Source010.PDF Restricted Access | 4.53 MB | Adobe PDF |  View/Open |
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