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Title:	Effect Of Curcumin On Bone Histo Morphometric Parameters In Ovariectomised Sprague Dawley Rats
Authors:	Nawwar Ghassan Ibraheem Al-Qaysi (P50876)
Supervisor:	Faizah Binti Othman, Assoc. Prof. Dr.
Keywords:	Effect Of Curcumin On Bone Histo Morphometric Parameters In Ovariectomised Sprague Dawley Rats Curcumin On Bone Histo Morphometric Parameters In Ovariectomised Sprague Dawley Rats Bone Histo Morphometric Parameters In Ovariectomised Sprague Dawley Rats In Ovariectomised Sprague Dawley Rats Universiti Kebangsaan Malaysia--Dissertations
Issue Date:	2-Apr-2013
Description:	Osteoporosis is a metabolic disease affecting both men and women especially postmenopausal women. Curcumin has been shown to influence bone metabolism in male rats. The aim of this study was to determine the effects of curcumin on bone histomorphometric parameter in ovariectomised rats, a postmenopausal osteoporosis model. Forty female rats were divided into five groups, namely: sham operated (Sham), sham operated and given curcumin (110mg /kg) (Sham+CL), ovariectomised control (OVX.C), ovariectomised and given curcumin 110mg /kg (OVX+CL), ovariectomised and treated with premarin 100µg /kg (OVX+E2). The rats were treated for 60 days. Right femur from each rat was taken for histomorphometric studies. A significant increase in trabecular bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N) and significant increase in trabecular separation (Tb.Sp) were noted in the OVX + CL group compared to OVX group. The eroded surfaces (ES/BS) of OVX+CL and Sham operated groups were significantly lower than the OVX C group. The OVC+CL had significantly higher osteoblast number (ObN) and significantly lower osteoclast number (OcN) when compared to the OVX C group. The osteoid volume (OV/BV) of Sham+CL was significantly higher than the OVX C group. OVX+CL had no significant increase in OV/BV compared to the OVC C group. Curcumin did not cause any significant difference in bone surface (OS/BS) compared to other groups. This study revealed that curcumin reduce bone resorption and increase bone formation, as shown by the lower eroded surface and increase in the number of osteoblast in ovariectomised rats. Therefore, curcumin has a potential anti-resorptive activity for the prevention of postmenopausal osteoporosis.,Master
Pages:	98
Publisher:	UKM, Kuala Lumpur
Appears in Collections:	Faculty of Medicine / Fakulti Perubatan

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